Blended genome exome sequencing method captures genetic variation cost-effectively in underrepresented populations

A new sequencing method called Blended Genome Exome (BGE) offers cost-effective and unbiased genetic variation capture. BGE combines low-pass whole-genome and deep whole-exome sequencing in one run, enabling broad genomic discoveries. It was applied to over 53,000 individuals from underrepresented populations. The method shows high concordance with existing technologies and provides a scalable platform for equitable genetic research.