Atomic structures of human SMUG1 enzyme reveal DNA repair mechanisms

phys.org

First atomic structures of human SMUG1, a DNA repair enzyme, have been revealed. This offers insight into how cells fix damaged DNA. The structures show SMUG1 interacting with damaged DNA bases, including those from cancer drugs. This could aid in developing new cancer therapies. The research also utilized neutron and X-ray crystallography, providing detailed information about the enzyme's active site.


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Atomic structures of human SMUG1 enzyme reveal DNA repair mechanisms | News Minimalist