AI predicts protein stability from structural mutations

phys.org

Researchers at the Institute for Basic Science have utilized AI, specifically AlphaFold2, to analyze how mutations affect protein stability, a key factor in preventing diseases like Alzheimer's. Their study, published in *Physical Review Letters*, found that structural changes predicted by AlphaFold correlate with stability changes, suggesting the algorithm encodes significant physical information. This advancement could enhance protein engineering and drug development efforts.


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AI predicts protein stability from structural mutations | News Minimalist