AAV tools target brain cells, aiding neurological disorder treatment

Researchers have developed new tools using adeno-associated virus (AAV) vectors to target specific brain cells, potentially aiding in treating neurological disorders. These tools act as "shuttles" to deliver DNA. Two studies from the Armamentarium consortium, led by Xiangmin Xu, focus on targeting brain endothelial cells and excitatory neurons. The research aims to bypass the blood-brain barrier and deliver therapeutic drugs with minimal side effects. The findings could lead to new gene therapies for Alzheimer's and other neurological diseases. The researchers are also exploring the mechanisms of these AAV tools to expand their use in neuroscience research and targeted therapies.