Study reveals liver-brain signals influence eating patterns linked to circadian rhythms

A new study from the University of Pennsylvania reveals how signals from the liver to the brain affect eating patterns linked to circadian rhythms. Disruptions in this communication, often seen in night shift workers, can lead to overeating and metabolic issues. Researchers focused on a protein called REV-ERB in the liver, which helps regulate the body's internal clock. When this protein was disrupted in mice, their eating patterns changed, leading to increased food intake during inactive hours. Restoring nerve connections improved their eating habits. The findings suggest that targeting liver-brain signals could help manage weight and metabolic disorders in people with irregular schedules. Future research may explore specific chemical signals involved in this communication pathway.