Scientists visualize opioid interaction with brain receptors to develop safer painkillers

Scientists visualized how opioids interact with brain receptors, potentially leading to safer painkillers and improved overdose antidotes. Using cryo-electron microscopy, researchers captured the mu-opioid receptor in action, revealing its molecular mechanics when activated by opioids and blocked by Narcan. This breakthrough offers a detailed understanding of a major drug target family, paving the way for designing more precise medications for pain, addiction, and other conditions.