Protective microglia subtype offers therapeutic potential for Alzheimer's disease

medicalxpress.com

Scientists identified a protective subtype of microglia that may offer a new therapeutic avenue for Alzheimer's disease. These microglia, with reduced PU.1 and co-expressed CD28, limit neuroinflammation and slow the buildup of amyloid plaques and tau protein. The discovery provides a mechanistic link between lower PU.1 levels and reduced Alzheimer's risk, suggesting microglia-targeted immunotherapies.


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Protective microglia subtype offers therapeutic potential for Alzheimer's disease | News Minimalist