Osaka favored over Siniakova in U.S. Open second round

Naomi Osaka is favored to defeat Katerina Siniakova in the second round of the U.S. Open on Thursday, September 3, with odds listing Osaka at -385 and Siniakova at +300. Osaka holds a 2-1 career record against Siniakova, including a win at Wimbledon in 2025, and boasts an 80% win rate at the U.S. Open, where she won titles in 2018 and 2020. However, Osaka needed tiebreakers to win both sets in her first-round match, while Siniakova won her opener in straight sets. The betting recommendation favors Siniakova to cover a +4.5 game spread, citing concerns about Osaka's inconsistent play. The match is scheduled for 11:30 a.m. EST on ESPN3, with the total set at 20.5 games.