Deep learning reveals RNA-level gene conservation between humans and mice beyond DNA sequence similarity

New research reveals RNA-level gene similarities between humans and mice, going beyond DNA sequence. Using deep learning on 777,000 transcriptomes, scientists identified genes with similar RNA patterns but different DNA, suggesting functional divergence and potential issues in mouse model research. This work provides a resource to assess the suitability of mouse models for studying specific human genes and also identified long noncoding RNA homologs.